Expert Guide on Long Protocol for IVF, Short, Soft and more
8 mins read

Expert Guide on Long Protocol for IVF, Short, Soft and more


Most of us have a general idea of the functioning of IVF. But what is less known (unless you have a treatment yourself) is that you might end up needing a completely different medication plan, or protocolDepending on your individual fertility base.

This could mean anything of a short approach to the long protocol for IVF, or even something more specialized. So how do you know which one suits you-and what happens if your plan should change?

For an expert overview here, we are delighted to associate ourselves with the brilliant team at Ferzrovia Fertility, London charm clinic for personalized fertility care. »»

Their philosophy focuses on transparency And Fertility care based on evidencetailor -made to your needs. With a team of some of the most experienced clinicians In the field, they offer A full spectrum of services – from the assessment and the treatment of fertility, to complementary holistic therapies and to mental health support, as well as expertise specialized in PGT-A, a loss of recurring pregnancy, hormonal health and more.

We sat with the consultant gynecologist and the accredited sub-specialist in reproductive medicine Dr Shirin KhanjaniMedical director at Fitzrovia Fertility, to talk about how she chooses the right starting point, when she pivots and the different ways in which a protocol can be adapted to your situation.

To Dr. Khanjani.

Why do several different IVF protocols exist and what is offered at Fitzrovia Fertility?

At Fitzrovia Fertility, we believe that IVF should never be a single size. As a tailor -made clinic, we offer highly personalized treatment plans designed around each unique fertility profile or torque.

There are several IVF protocols in clinical use, and Each serves a different goal. The right approach depends on several factors, including:

  • age
  • ovarian reserve
  • hormonal levels
  • sperm settings
  • IVF results.
  • Underlying conditions such as endometriosis or sopk.

Our consultants are deeply involved in research, frequently assisted and present to international conferences, bringing the latest techniques based on evidence to our patients in real time.

We offer a full range of protocols of long and short approaches to more innovative strategies, to adapt the treatment according to time sensitivity, ovarian reserve and medical requirements if necessary!

When would you recommend the short IVF protocol?

The short IVF protocol is a well -established and widely used approach. It is often recommended if You have a good ovarian reserveor if Male factor infertility is the main concern.

It is also common for younger women,, IVF patients for the first timeOr anyone where a faster and simpler cycle is clinically.

THE IVF Short step by step protocol

A short typical protocol works as follows:

  1. Day 2 cycle – 3: Start daily injections of hormonal stimulation.
  2. Day 5 – 7 in advance: Add drugs to avoid premature ovulation.
  3. Monitoring: Ulick ultrasounds and tests to check the growth of follicles.
  4. Triggering injection: Administered once the follicles are mature.
  5. Egg collection: Carried out 36 hours after the trigger.
  6. Fertilization and development of embryos: In the laboratory.
  7. Transfer of embryos or freezing: Depending on your personalized plan.

Here, to the fertility of Fitzrovia, I will often add the priming of progesterone of day 14 of the previous cycle, helping the follicles to develop in a more synchronized manner and making the response to the stimulation more predictable.

Who benefits the most of the long protocol for IVF?

Long protocol can be particularly effective for patients affected endometriosis,, adenomyosisOr Those who provide a new transfer of embryos.A

It is also a strong option when a previous one A short protocol led to fewer mature eggs What planned.

By removing your natural cycle before stimulation (often called “Downraguling” by IVF doctors), long protocol allows more control over the growth of follicles. This can lead to better synchronization and maturity of eggs in some cases.

The Typical Protocol FIV chronology

This is what a long IVF protocol might look like:

  1. Day 14 of the previous cycle: Start priming progesterone priming.
  2. Day 21: Start medication to remove the natural cycle.
  3. 2 – 3 weeks later: Start ovarian stimulation after confirmation of deletion.
  4. Surveillance, trigger, egg collection and embryos creation Follow as usual.

Transfer or freezing costs Depending on your preparation for the endometrium.

Are there other personalized IVF protocols outside the short and long standard?

Yes! This is where our shop, a highly tailor -made approach to the fertility of Fitzrovia really shines.

We regularly offer:

  • Light stimulation protocols: Lower doses of drugs with fewer side effects, ideal for women with a high FSH or those looking for a softer cycle.
  • Cycles upon reception of estrogen: Used to improve the growth and responsiveness of follicles, especially in women with a lower ovarian reserve.
  • Double stimulation (duostim): A advanced approach involving two stimulation in a cycle, particularly beneficial in cases sensitive to time or for patients with a small number of eggs.
  • Protocols at progestin prices: Often used for freezing eggs or embryos, a lower cost and less risk of ovarian hyperstimulation syndrome (OSH) with fewer injections.

When (and why) could a protocol change?

Sometimes swivel in the middle of the cycle or adjustment for the next round can make all the difference. »»

I could suggest changing the IVF protocol when:

  • The numbers of eggs or maturity are lower that planned
  • The fertilization or the development of embryos is sub-optimal
  • Previous cycles Haven did not lead to the desired result
  • There is evidence of Low ovarian reserve Or bad answer

At Fitzrovia Fertility, our team continuously follows the progress of your cycle and uses data in real time to help us adapt quickly to maximize your chances of success.

What IVF protocol is the best for specific situations?

Best IVF protocol for the low ovarian reserve

For a weak ovarian reserve, I would focus on both quality and quantity.

At Fitzrovia’s fertility, your plan may include:

  • Estrogens priming For better growth in follicles
  • Duostim To collect eggs in the two phases of a cycle
  • Hormonal growth supportif applicable
  • Light stimulation with close surveillance

Best IVF protocol over 40 years

There is no better protocol for women over 40 – your treatment must be carefully adapted.

Depending on your ovarian reserve, your story and your goals, I could recommend:

  • Estrogens priming
  • Light stimulation
  • Duostim
  • The long protocol

Where does PGT-A arrive?

Pré-implantation genetic test for aneuploidism (PGT-A) is also often advised in this age group, and is something we offer in Fitzrovia Fertility. As the probability of chromosomal anomalies increases with age, PGT-A helps to identify embryos with the highest implantation potential, reducing the risk of miscarriage or stranded cycles. »»

In short – This does not increase the number of embryos, but it improves the possibility of choosing the most viable.

Best IVF protocol for endometriosis

For endometriosis, Fitzrovia’s fertility works alongside the main gynecologists of UCLH, Cleveland Clinic and other endometriosis centers. »»

My approach may include:

  • Short or long protocolDepending on the severity of the disease
  • Drugs specific to reduce inflammation
  • Strategic timing egg collection and embryos creation
  • Transfer of frozen embryos in A natural or hormonely deleted cycle

Icy eggs and embryos is also offered for preserving fertility, if your endometriosis is moderate to severe.

Long or short IVF protocol for sopk?

With the SOPK, my priorities would be to reduce the risk of sho and maintain a stable hormonal environment for transfer.

This often involves:

  • Short protocol with doses of lower drugs
  • Tailor -made drugs To trigger egg maturation
  • Getting all embryos for transfer to a subsequent cycle

Ready to find the best suitable IVF treatment?

After talking with Dr. Khanjani, there is no “size protocol”.

Pass your next steps? Jump on the Fitzrovia Fertility website to find out more about their success services and rate, and Reserve in a consultation.

If your path leads you to IVF, their team will work with you to find a protocol that seems good, corresponds to your calendar and is supported by the latest care based on evidence.

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